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2 edition of Transcription factors 1: bZIP proteins found in the catalog.

Transcription factors 1: bZIP proteins

Helen C. Hurst

Transcription factors 1: bZIP proteins

by Helen C. Hurst

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  • 32 Currently reading

Published by Academic Press in London .
Written in English


Edition Notes

StatementHelen C. Hurst.
SeriesProtein profile -- vol.2, issue 2
ID Numbers
Open LibraryOL18092348M

Analysis of a Conserved Multisection Domain in Subset bZIP Transcription Factors. The transcription factors SREBP 1 and 2 are key components in the homeostatic control of sterol and fatty acid metabolism (Brown and Goldstein, ; Horton et al., ). These proteins are regulated by compartmentalization, trafficking, and subsequent cleavage. In addition to the first type of Zn 2+-binding site described with two Cys and two His (Cys 2-His 2), there are two major variations to first is the Cys 2-Cys 2 type, which is characteristic of steroid receptor transcription factors such as the glucocorticoid receptor or estrogen receptor. We will consider them in more detail later with the discussion of intracellular signal.

  Since TGA transcription factors belong to the bZIP protein family, we first accessed the browse gene family function of the Soykb database and selected the Author: Ihteram Ullah, Ihteram Ullah, Mahmoud Magdy, Mahmoud Magdy, Lixiang Wang, Mengyu Liu, Xia Li. Plant Transcription Factors: Evolutionary, Structural and Functional Aspects. is the only publication that provides a comprehensive compilation of plant transcription factor families and their complex roles in plant biology.. While the majority of information about transcription factors is based on mammalian systems, this publication discusses plant transcription factors, including the.

bZIP Transcription Factors The basic leucine zipper (bZIP) family contains a conserved bZIP domain which is composed of a highly basic region for nuclear localization and DNA binding at the N-terminus and a leucine-rich motif for dimerization at the C-terminus (Landschulz et al., ; Hurst, ).Cited by: The C/S 1 bZIP signaling network consists of nine partially redundant transcription factors, which preferentially heterodimerize, and hence are functionally connected. The C/S 1 network acts in response to low-energy/nutritional starvation signals mediated by SnRK1, HXK1 (HEXOKINASE 1), and a sucrose-induced repression of translation (SIRT Cited by:


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Transcription factors 1: bZIP proteins by Helen C. Hurst Download PDF EPUB FB2

Get this from a library. Transcription factors 1: bZIP proteins. [Helen C Hurst] -- Concentrates on a group of DNA-binding transcription factors which contain a leucine zipper as a common structural motif required for protein dimerization.

Includes 2 fold-out sections showing. Basic leucine zipper (bZIP) proteins are a class of transcription factors characterized by a basic leucine zipper motif, which allows for both dimerization and sequence-specific DNA-binding interactions (Ellenberger, ).

Transcription factors containing bZIP domains are found across eukaryotes, from budding yeast to humans. In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the right cell at the right time and in the right. bZIP proteins are transcription factors that consist of three modular functional regions mediating dimerization, DNA binding and transcriptional regulation.

The hallmark of these proteins is the bZIP (basic region, leucine zipper) domain, a well-defined motif in eukaryotic proteins (1, 2).The basic region of the bZIP domain, rich in lysines and arginines, represents the DNA contact surface.

In bZIP transcription factors, DNA binding and dimerization are mediated by the bZIP motif, which consists of a region rich in basic amino acids and an adjacent bZIP that consists of a 4–3-heptad repeat of hydrophobic and nonpolar residues (for review, see Hurst, ).

The bZIP is required for dimerization of the protein prior to binding to. Introduction. The c-Jun dimerization protein 2 (JDP2) is a basic leucine zipper protein member of the AP-1 superfamily of transcription factors [].JDP2 is constitutively expressed in all tissues and cell lines tested [].The bZIP domain of JDP2 shares a high degree of homology with the activating transcription factor 3 (ATF3) protein [].ATF3 is an immediate early gene that is highly induced Cited by: Transcription factors.

Sequence-specific DNA-binding factor that controls the rate of transcription by promoting (activator) or blocking (repressor) the recruitment of RNA polymerase. Other proteins critical for regulating transcription lack DNA-binding domains: coactivators, corepressors, deacetylases, methylases, chromatin remodelers.

ISBN: OCLC Number: Notes: "2nd edition published as Protein Profile volume 2 issue 2: Transcription Factor 1: bZIP proteins, "--Title page verso. Several families of transcription factors have been identified both in animals as well as plants.

The basic Leu zipper (bZIP) transcription factor family is among the largest and most diverse dimerizing transcription factor families.

bZIP transcription factors owe their name to their highly conserved bZIP domain composed of a basic region and a Leu zipper (Hurst, ). F-bZIP transcription factors bZIP19 and bZIP23 are the central regulators of the zinc deficiency response in Arabidopsis, and phylogenetic analysis.

Different combinations of transcription factors within DNA-binding multiprotein complexes allow individual proteins to partake in multiple different regulatory pathways. Many transcription factors can form homo- and heterodimers (or oligomers) with different partners, thus modulating DNA-binding specificity and affinity and/or the recruitment Cited by: Gene Family Locus ID Gene/Protein Name Submitter Description; bZIP Transcription Factor Family: At1g ABF1: At1g ABF2: At5g AtbZIP1: bZIP family transcription factor.

The leucine zipper region of ATF proteins is also similar to that of the AP-1/c-jun family of transcription factors, whose DNA-binding site differs from the ATF-binding site at a single position.

Two bZIP proteins from Antirrhinum flowers preferentially bind a hybrid C‐box/G‐box motif and help to define a new sub‐family of bZIP transcription factors 5 January | The Plant Journal, Vol. 13, No.

4Cited by: Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a DNA-binding and dimerization domain This subfamily is composed predominantly of APlike transcription factors including Saccharomyces cerevisiae YAPs, Schizosaccharomyces pombe PAP1, and similar proteins.

TATA binding protein (TBP) and transcription factor IIB (TFIIB) are key factors for the assembly of eukaryotic transcription initiation complexes. We used a rice whole-cell extract in vitro transcription system to characterize the functional interactions of recombinant plant TBP and TFIIB.

Bacterially expressed rice TBP (OsTBP2) bound to the TATA box of the rice pal gene encoding Cited by:   For HY5 immunoblot analysis, total proteins were extracted in extraction buffer (50 μ m EDTA, m TRIS‐HCl pH 8, % w/v SDS, 10 m m NaF, protease inhibitor tablet, 1 m m DTT, m NaCl, 15 m m β‐glycerolphosphate, 15 m m p‐nitrophenyl phosphate).

Proteins were separated by SDS/PAGE and transferred to polyvinylidene difluoride Cited by: 5. AP-1, which includes such proteins as c-Jun and c-Fos, is part of the same family of bZIP transcription factors that includes yeast Yap1 (Moye-Rowley et al., ).

Like Yap1 and OxyR, the DNA binding activity of AP-1 is regulated through a redox mechanism, and in certain cell types, AP-1 also is activated by prooxidants such as hydrogen by: Transcription factors are often classified based on the sequence similarity and hence the tertiary structure of their DNA-binding domains: 1 Superclass: Basic Domains Class: Leucine zipper factors (bZIP) Family: AP-1(-like) components; includes (c-Fos/c-Jun) Family: CREB.

The production of these functional proteins is widely regulated by specific transcription factors [58, 65]. Transcription factors (TFs) are considered to be the most important regulators that control genes and gene clusters. Many families of transcription factors have been demonstrated to play a role in stress responses in by:.

The basic regions of these proteins, named DPBF‐1 and 2 (Dc3 Promoter‐Binding Factor‐1 and 2), respectively, are nearly identical to each other and are similar to the plant G‐box binding factor GBF‐4. Outside the basic region, however, DPBF‐1 and 2 diverge significantly from Cited by: In group II, AtbZIP35, AtbZIP37 and AtbZIP39 belonged to ABF-type bZIP transcription factors, which are induced by ABA and are critical in plant abiotic stresses tolerance [37,38].

Therefore, the results of our evolutionary relationship analysis imply that bZIP proteins in the group II might be associated with by: 1.A yeast two-hybrid system using NPR1 as the bait revealed the isolation of four cDNAs from rice, rTGA, rTGA, rTGA and rLG2, which encode proteins belonging to bZIP transcription factors.

The rTGA, rTGA and rTGA proteins show 75%, 76% and 78% identity, respectively, with the TGA2 protein from Arabidopsis, the ability of which Cited by: